Resident Evil Requiem: Complete Guide to the Lead Researcher’s Office Puzzle Box Combinations

As you delve further into the Rhodes Hill Care Center in Resident Evil Requiem, your quest for escape items directs you to the Lead Researcher’s Office. Here, you will encounter yet another locked Puzzle Box, reminiscent of the one found in the Chairman’s Office, but this box offers a crucial item necessary for your progression.

Unlike the Chairman’s puzzle box, however, this one requires an initial step to unlock. You will need a specific item to trigger the box, as it is secured with a physical lock.

Unlocking the Puzzle Box

Puzzle interface featuring combination lock with celestial symbols from Resident Evil Requiem
For those in a rush, the correct combination for the Puzzle Box is: Star – Sun – Moon – Sun

Obtaining the Corrosive

A player inventory screen in Resident Evil Requiem showing items including 'Corrosive'
The Corrosive is essential to dissolve the Puzzle Box’s lock.

Before addressing the combination, take note that the Puzzle Box is secured with a sturdy padlock. Unfortunately, Grace’s tools will not help you here; instead, you must locate the Corrosive, which can be found in the Conference Room to safely dissolve the lock.

Finding the Combination

These hints scattered about the environment will unveil vital pieces of the Puzzle Box’s combination.

Rewards for Your Efforts

Upon successfully unlocking the Puzzle Box, you will be rewarded with two significant items:

  • Sun Quartz: This is the second of three essential items required for your escape from the Rhodes Hill Care Center.
  • Organ Transport Box Note: A crucial note containing guidance on unlocking the organ transport box in the facility’s Garage. The artificial organ within is vital for resolving a later puzzle.

With these items, you’re one step closer to unraveling the mysteries of Rhodes Hill Care Center.

This guide is based on a complete playthrough of the Steam 1.0 version, played at Standard (Classic) difficulty. Screenshots are taken from the same version for accuracy.

Source & Images