32 Isekai Anime and Manga Featuring Gender-Bending Main Characters

32 Isekai Anime and Manga Featuring Gender-Bending Main Characters

Overview of Gender-Bending Isekai Trends

  • Gender-swapping narratives in isekai offer intriguing new angles.
  • Numerous series creatively explore themes of gender-bending.
  • The webcomic Magician Girl presents an innovative take in a VRMMO setting.

The isekai phenomenon has captured the imagination of anime and manga enthusiasts for over a decade, driving a wave of engaging stories that take characters from one universe to another. Whether through time travel in classics like Inuyasha, magical journeys in Magic Knight Rayearth, or fully immersive settings like Sword Art Online, these tales spark curiosity.

A unique aspect of some isekai stories includes the transformation of protagonists, as seen in series like Mushoku Tensei: Jobless Reincarnation and That Time I Got Reincarnated As a Slime. These narratives add further depth by introducing gender swaps, enhancing the storytelling with fresh perspectives and unique character arcs.

Updated March 9, 2025, by David Heath: Despite the impressive collection of nearly 30 titles, gender-bending manga and anime continue to evolve, maintaining their appeal. Topics of gender fluidity and transformation consistently intrigue audiences, paralleling the journeys of transgender individuals or simply adding humor and depth to narratives. As the isekai genre develops, opportunities for innovative takes on gender, societal norms, and sexuality remain abundant, prompting ongoing exploration of this thrilling literary terrain.

1 Magician Girl, Do Your Best To Return To Your World!

MyAnimeList Score: N/A

Gender-Bending Isekai Protagonists - Magician Girl Do Your Best
  • Illustrated by Teresa Wakamiya.
  • 3+ Volumes, 18+ Chapters.
  • Fan Translations only.

Magician Girl, Do Your Best to Return to Your World (or “Onna Majutsushi-san, Moto no Sekai e Kaeru Tame ni Ganbarimasu”) is a relatively recent addition to the genre. Although it has yet to be rated on platforms like MyAnimeList or Anime-Planet, it intriguingly twists the Fantasy Knockout premise, showcasing its characters’ attempts to navigate their transformed states in a quest to return home.

The plot follows friends Rintaro and Haruto as they immerse themselves in the VRMMO ‘Eternal Maze Online’, a game that nearly serves as a second life. Their adventure takes a dramatic turn when Rintaro acquires the mysterious Reincarnation Jewel, causing both him and Haruto to manifest as their in-game avatars — Haruto as a male Paladin and Rintaro as a female magician. Their journey through this fantasy realm becomes a firsthand survival challenge while Rintaro seeks to regain his original male body.

2 Gender X Bug

MyAnimeList Score: N/A

Gender Bending Isekai Protagonists - Gender X Bug
  • Written & Illustrated by Yuki Azuki.
  • 2 Chapters.
  • Fan Translations only.

In the realm of isekai, the role of developers in creating hyper-immersive MMORPGs often raises eyebrows, particularly with unexpected bugs leading players to their avatars. In Gender X Bug (also known as Seibetsu Bug ga Hassei Shimashita!?), the consequences of a game glitch are laid bare.

Haruki, a timid boy, finds solace in his fantasy game, ‘Mirage Universe’.However, fate takes a twist when an accident during a thunderstorm transports him into the game as a female character, while his friend Karen becomes the male hero. Haruki’s transformation poses challenges, and his journey of self-discovery begins as he navigates life in this altered state.

3.The Battle of Isekai

MyAnimeList Score: N/A

Gender Bending Isekai Protagonists - Youjo Nobunaga no Isekai Touitsu
  • Illustrated by Ichiko Kameyoshi.
  • 1 Chapter.
  • Fan Translations only.

Youjo Nobunaga no Isekai Touitsu or ‘Maiden Nobunaga’s Isekai Unification, ’ ventures into historical reinterpretation. The storyline postulates that Nobunaga’s soul was reborn in an alternate world, where he inhabits the body of Roselia Romanesco, the eldest daughter of a declining lord. This reincarnation serves not just as a plot device but as a vehicle for agency, as Roselia sets forth on a path to fulfill her former ambitions.

As she navigates her new identity and grapples with the legacy of Nobunaga, who in history was betrayed and met a tragic end, Roselia embraces her purpose and embarks on a quest for conquest in her new reality.

4 When I Reincarnated, I Was The Heroine, And He Was The Hero

MyAnimeList Score: 6.22

Gender Bending Isekai - I Was the Heroine
  • Written and Illustrated by Moto Mizuno.
  • 5 Volumes, 45 Chapters.
  • Fan Translations only.

Moto Mizuno’s When I Reincarnated, I Was the Heroine, and He Was the Hero reflects a similar vein to Life With an Ordinary Guy Who Reincarnated into a Total Fantasy Knockout. Here, Keito Azumi, a typical schoolboy, meets a fatal end and is reincarnated as a fantasy heroine. His best friend Taiga transitions into the valiant hero, deftly vanquishing adversaries while Keito grapples with new challenges and comedic pursuits.

While it hasn’t achieved the same acclaim as its contemporaries, its engaging pacing and humor have garnered a dedicated fanbase.

5 Reborn As The Hero’s Daughter! Time To Become The Hero Once More!

MyAnimeList Score: 6.31

Gender-Bending Isekai- Reborn as the Hero's Daughter
  • Illustrated by Amane Kotodera.
  • 4 Volumes, 24 Chapters.
  • Fan Translations only.

Reborn as the Hero’s Daughter! Time to Become the Hero Once More (Eiyuu no Musume toshite Umarekawatta Eiyuu wa Futatabi Eiyuu wo Mezasu) presents a fresh angle on reincarnation narratives. Reid, the legendary hero of yore, finds himself reincarnated as Nicole, a girl who is both the daughter of his former allies and possesses his past life’s prowess.

While Nicole must navigate the complexities of her new identity, her unique lineage empowers her to confront her former foes with newfound determination.

6 She Professed Herself Pupil of the Wise Man

MyAnimeList Score: 6.33 (Anime) 7.08 (Manga)

Best Gender-Bender Isekai - She Professed Herself Pupil of the Wise Man
  • Illustrated by Dicca Suemitsu.
  • Manga: 10+ Volumes, 73+ Chapters. Available in English via Seven Seas Entertainment.
  • Anime: 1 Season, 12 Episodes. Available on Crunchyroll.

In contrast to many isekai adaptations, the anime version of She Professed Herself Pupil of the Wise Man hasn’t received as favorable a reception compared to its manga or light novel origins. The premise follows Kagami, who made his mark in ‘Arch Earth Online’ as Danblf, one of the game’s Nine Great Sages. After an unexpected nap, he awakens to discover he has transformed into a young girl named Mira, who claims to be Danblf’s pupil, setting out on a quest to reunite with the remaining sages.

The story successfully combines traditional isekai elements with engaging character arcs, inviting readers to join Mira on her journey of self-discovery as she seeks to prove herself anew.

7 More Peace Than a Harem: In Another World, Let Me Be a NEET Princess in Peace!

MyAnimeList Score: 6.35

Gender Bending Isekai Protagonists - More Peace Than a Harem
  • Illustrated by Frog.
  • 1+ Volume, 9+ Chapters.
  • Fan Translations only.

While many titles in the gender-bending category lean toward fan service, More Peace Than a Harem adopts a more subtle approach. The narrative centers on Kishibe, who aspired to escape his mundane work life and achieve NEET status, only to have fate intervene after a life-altering incident with a truck. Reincarnated as Iris, a princess of means, Kishibe navigates the challenges of royal life while avoiding the romantic advances of suitors.

This title explores comedic elements and social themes, providing a unique lens on the conflicts surrounding privilege and desire.

8 Final Girl

MyAnimeList Score: 6.42

Final Girl manga panel
  • Written and Illustrated by Yō Kokikuji.
  • 1 Chapter.
  • Fan Translations only.

In a world where the isekai narrative can often become predictable, Yō Kokikuji’s Final Girl diverges from the formula. The story revolves around a man who awakens in a slasher film, now inhabiting the body of Summer, a character often doomed to perish early. The narrative challenges the conventions of horror while holding the potential for a twist as she strives for survival and seeks to outwit the narrative itself.

9 Since I Have Been Reincarnated As The Daughter Of A Duke, I, The “Girl Inside, ”Will Enjoy Being A Girl As Much As I Can!

MyAnimeList Score: 6.42

Gender Bending Isekai Anime Manga - Daughter of a Duke
  • Illustrated by Chagen.
  • 3+ Volumes, 24+ Chapters.
  • Fan Translations only.

With a title that reflects both its ambition and irony, Since I Have Been Reincarnated as the Daughter of a Duke tells the tale of a man reborn as young Miranda Mirandiehl. Navigating a fantasy society drawing on 18th-century aesthetics, the new life allows the protagonist, who identifies as a woman, to embrace her true self and explore femininity, all while learning how to manipulate the societal norms around her for her advantage.

By framing gender identity within an isekai setting, the story offers commentary on societal expectations while delving into character development.

10 This Is Screwed Up, But I Was Reincarnated As A GIRL In Another World!

MyAnimeList Score: 6.56

Gender-Bending Isekai - This Is Screwed Up
  • Illustrated by Keyaki Uchiuchi.
  • 23+ Volumes, 116+ Chapters.
  • Available in English via Seven Seas Entertainment.

This groundbreaking title begins as a light novel before transforming into a manga under the guidance of Keyaki Uchiuchi.This Is Screwed Up, But I Was Reincarnated as a GIRL in Another World chronicles the life of Ren, a formerly male scientist who finds herself enslaved in a fantasy land. Drawing on memories from her previous life, Ren uses her scientific acumen and burgeoning magical capabilities to redefine her circumstances and forge a new path.

11 Fake Saint Of The Year: You Wanted The Perfect Saint? Too Bad!

MyAnimeList Score: 6.57

Best Gender-Bender Isekai - Fake Saint of the Year
  • Illustrated by Ekakibit.
  • 3+ Volumes, 35+ Chapters.
  • Fan Translations only.

In the expansive world of otome games, many characters find themselves engaging with their tropes in unexpected ways, as seen in Fake Saint of the Year. The protagonist, Fudo Niito, awakens in the role of Elize, a character usually cast as an antagonist within the game. As someone who initially lacks malicious intent, Fudo-Elize chooses a different path, seeking to help the game’s heroine while embracing the role of a “fake saint.”

This unique twist on gender and character dynamics results in an entertaining exploration between villainy and heroism.

12 Maze: The Mega-Burst Space

MyAnimeList Score: 6.59 (Anime), N/A (Manga)

Gender-Bending Isekai Anime & Manga - Maze Mega-Burst Space
  • Illustrated by Rei Omishi.
  • Manga: 6 Volumes, 44 Chapters.
  • Fan Translations only.
  • Anime: 1 Season, 25 Episodes. DVD Only.

For fans seeking a nostalgic trip back to the 1990s anime and manga boom, Maze: The Mega-Burst Space serves as an exemplar of pre-bust isekai narratives. The story follows Maze as she inadvertently becomes a hero tasked with rescuing Princess Mill amid conflicts with hostile forces. This series not only delivers a dose of humor and adventure but also highlights the blend of gender transformation and comedy.

13 ReLive Game of Wandering Reincarnations

MyAnimeList Score: 6.62

Gender Bending Isekai - Revival Game
  • Illustrated by Haruto Hino.
  • 4 Volumes, 26 Chapters.
  • Fan Translations only.

ReLive Game of Wandering Reincarnations provides a thoughtful examination of life and redemption in a fantasy context. The protagonist, Manatsu Asai, faces rejection and danger, ultimately ending his life trying to protect another. When reincarnation grants him a new form — that of the swordswoman he attempted to save — it raises questions about sacrifice and destiny. The narrative offers a blend of dark humor and emotional depth, making it a compelling read.

14 Herscherik R: Heroic Tale of the Reincarnated Prince

MyAnimeList Score: 6.80

Gender-Bending Isekai - Herscherik R
  • Illustrated by Yuyu Yuzuki.
  • 2+ Volumes, 10+ Chapters.
  • Fan Translations only.

Herscherik R: Heroic Tale of the Reincarnated Prince takes a rare female-to-male transformation route within the isekai genre. Ryōko Hayakawa meets an untimely fate yet finds herself reborn as Prince Herscherik. This exciting narrative unfolds as he grapples with reforms within a corrupt royal system, leveraging his past life’s skills to enact change.

15 I Am Alice: Body Swap In Wonderland

MyAnimeList Score: 6.87

Gender Bending Isekai Anime Manga - I Am Alice
  • Written & Illustrated by Ayumi Kanō.
  • 3 Volumes, 14 Chapters.
  • Available in English via Seven Seas Entertainment.

A nostalgic take on a classic narrative, I Am Alice: Body Swap In Wonderland finds inspiration in Lewis Carroll’s timeless tale. The story follows Makoto, who is drawn into Wonderland in a peculiar body swap scenario with Alice. To revert their forms, he must navigate the peculiarities of Wonderland, facing quirky characters and labyrinthine challenges along the way.

16 Did I Seriously Just Get Reincarnated As My Gag Character?!

MyAnimeList Score: 7.03

Gender Bending Isekai Anime Manga - Did I Seriously Just Get Reincarnated as My Gag Character
  • Illustrated by Kamuragi Amano.
  • 6+ Volumes, 27+ Chapters.
  • Available in English via J-Novel Club.

Based on Otonashi’s light novel, Did I Seriously Just Get Reincarnated as My Gag Character begins with the protagonist, Tōru, who faces an untimely demise and finds himself reborn as Nacht, a comically exaggerated character in an MMORPG. This humorous series beautifully mixes elements of fantasy and comedic misunderstanding, as Nacht navigates newfound abilities and strange antics while attempting to succeed in a game designed for survival.

17 Thank You, Isekai!

MyAnimeList Score: 7.04

Best Gender-Bender Isekai - Thank You, Isekai
  • Illustrated by Zianazu.
  • 6+ Volumes, 56+ Chapters.
  • Available in English via Comikey.

Those craving a blend of adventure and camaraderie might enjoy Thank You, Isekai!. The plot revolves around two 30-something friends, Chiba and Sheina, who after suffering together through life’s misfortunes, find themselves reincarnated as women in a fantastical world. Their story explores their new lives, laden with challenges, emphasizing the importance of friendship as they adapt to this unexpected reality.

18 Only Sense Online

MyAnimeList Score: 7.12

Gender-Bending Isekai - Only Sense Online
  • Illustrated by Un Hanikura.
  • 20+ Volumes, 118+ Chapters.
  • Fan Translations only.

Adapted from the light novel by Zachou Aloha and Yukisan, Only Sense Online features a captivating gender-bending narrative within a VR MMORPG. As Yun navigates this hyper-realistic realm with underwhelming stats that mistakenly transform his avatar into a female character, he uncovers hidden strengths as a support class, redefining perceptions of capability in gaming and realizing potential where least expected.

19 Life With An Ordinary Guy Who Reincarnated Into A Total Fantasy Knockout!

MyAnimeList Score: 7.13 (Anime), 7.49 (Manga)

Gender-Bending Isekai - Fabiniku
  • Illustrated by Shin Ikezawa.
  • Manga: 13+ Volumes, 203+ Chapters. Available in English via Seven Seas Entertainment.
  • Anime: 1 Season, 12 Episodes. Available on Crunchyroll.

Life with an Ordinary Guy Who Reincarnated into a Total Fantasy Knockout emerges as a standout entry in the isekai genre. Chronicling the evolution of friendships, Tachibana and his charming friend Jingūji undergo transformations that blur the lines of gender dynamics. The goddess’s playful twist forces them to navigate not only perilous quests but also burgeoning romantic feelings amidst the backdrop of a fantastical world.

20 When I Reincarnated, I Was A Princess. So I’m Aiming To Become The Ultimate Sorceress

Anime-Planet Score: 3.60/5 Stars

Gender Bending Isekai - Ultimate Sorceress
  • Written and Illustrated by Akira.
  • 4+ Volumes, 22+ Chapters.
  • Fan Translations only.

Delving into themes of gender and agency, When I Reincarnated, I Was a Princess. So I’m Aiming to Become the Ultimate Sorceress explores Princess Isabella’s quest for empowerment despite societal limitations. After dying, she inhabits a new body but must disguise her true identity to venture into sorcery, challenging the cultural expectations of her new environment. This unique narrative juxtaposes the burdens of gender roles with the determination for self-actualization.

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